Ahead of this weekend’s fixtures, here’s a recap of what happened last time out.
It was back into action in all eight divisions for the first time this season although Covid problems caused some games to be postponed.
Premier Division leaders Milton were not in action but stay top by three points from De La Salle who won a vital game against Mellor by 4-2 to keep up their 100% record with a game in hand on the leaders.
The only other game played in the top flight ended in a 1-1 deadlock between Abacus Media and Manchester Polonia.
There was more action in Division One with a congested title race seeing Signol Athletic stay one point clear of three other teams after a 3-1 win at Hadfield Athletic.
Irlam Tigers were without a game but stay in second spot on goal difference from Old Stretfordians and Chadderton Cott.
Strets fought hard to win a point as they shared eight goals with Shaw Athletic.
Strets took an early lead through Steve Drabble but Shaw hit back quickly to lead 2-1 with Sheldon Clarke on target and it was ebb and flow from then on.
Chadderton Cott were also without a game and Didsbury moved to within a point of them as they won their second successive game by 4-2 at Bury Ams.
There were plenty of goals in what looks set to be a very exciting Division Two and new boys Baguley Athletic hit the top with an impressive 5-0 win at another new team Eccles United.
South Manchester are in second spot on goal difference after winning an exciting home encounter with Newton by the odd goal in seven.
Netting for South were Chris Lydon, Reece Horan (two) and John Chukwu while Newton showed their fighting spirit with a hat-trick from Jake Hatton.
Wythenshawe Wanderers were the big hitters in the division with an emphatic 8-0 win at Stoconians and Hattersley also kept an immaculate clean sheet in a 2-0 win over Bedians.
Division Three is also looking to be a very competitive with plenty of close games seeing just a point separating the top six teams and four teams are level on points at the top of the table.
The early leaders are Radclyffe who shared the spoils in a 2-2 deadlock with second-placed Village Manchester.
In the mix are Hooley Bridge Celtic who impressed with a 3-0 win at Woodhouses and Chadderton Park who beat Stoconians reserves 3-1.
The other games in the division saw AFC Stockport beat Abacus Media reserves 4-2 and Aldermere and Salford Albion drew 2-2.
Plenty of action in Division A and Moston Brook reserves hit the heights with a big 10-3 win over Milltown Firgrovia.
Salford Storm are level on points with Moston Brook after winning a nerve-jangling game with Trafford United reserves by 5-4.
North Walkden reserves picked up their first points with a comfortable 4-2 win over Great Manchester FC but the other games were close affairs.
Salford Vics reserves drew 2-2 hosting Santos and there were no goals in the games between Woodsend Athletic and Milton reserves and AFC Oldham reserves and Stretford Paddock Development.
Division B had its first action of the season and there was a big opening day win for AFC Oldham reserves in their local derby with Moston Brook thirds.
Aldermere reserves were in an exciting local derby at Old Strets reserves and were delighted to emerge with a breathless 4-3 victory.
Parrs Wood Celtic had had a close encounter with Great Manchester FC reserves winning 2-1 and the other game was locked at 1-1 between Heaton Mersey and Flixton JFC.
Plenty of action in the opening day for Division C with the top scorers being Dukinfield Athletic who eased to a 9-0 win over Stoconians thirds.
There were also wins for Salford Storm reserves by 4-1 at AFC Stockport Warriors, Bury Ams thirds by 3-1 at Chadderton Park thirds, Urmston Town Vale 3-0 over Altrincham Hale, Mellor thirds by 3-1 over Eccles United reserves and Village Manchester reserves by 3-2 over Staly Lions.
The final action was in Division D and there were goals galore led by Moston Brook fourths by 7-1 at new boys Altrincham Hale.
Bury Ams fourths won by the odd goal in nine hosting Irlam Tigers thirds and it was also close at Didsbury reserves who went down by 5-3 to Milltown reserves.
The last game saw Whalley Range reserves win by 4-2 at Mellor Development to set up the usual lively celebrations back at their club.